Article Title and Bibliographic Information: Age as a determinant of outcomes for patients with oral cancer.Goldenberg D, Brooksby C, et al.Oral Oncol 2009;45(8):e57-61.Reviewer: Mark D. Macek, DDS, DrPHPurpose/Question: How does 5-year survival rate for oral cavity squamous cell cancer compare for older and younger adults in the United States, using 4 specific age thresholds and controlling for sex, race, cancer site, and stage of disease?Source of Funding: Information not availableType of Study/Design: Retrospective cohort studyLevel of Evidence: Level 2: Limited quality, patient-oriented evidenceStrength of Recommendation Grade: Not applicable (Source: The Journal of Evidence-Based Dental Practice) Source: MedWorm: Oral Cancer
Tag: squamous
Younger Adults with Oral Cavity Squamous Cell Cancer have a Significantly Higher 5-Year Survival Rate than do Older Adults in the United States, Controlling for Patient- and Disease-Specific Characteristics
Tags: 5year, Adults, Cancer, Cavity, cell, Characteristics, Controlling, DiseaseSpecific, Higher, in the, Older, Oral, Patient, Rate, Significantly, squamous, States, survival, than, United, Younger
ORIGINAL ARTICLE: Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue
(Source: Oral Diseases)
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Source: MedWorm: Oral Cancer
Tags: Article, carcinoma, cell, cyclophilin, expression, increased, Original, peroxiredoxin, squamous, tongue
Gender specific quality of life in patients with oral squamous cell carcinomas
Conclusions:
The data obtained within this investigation demonstrated that gender had the most significant power on the subjectively perceived postoperative quality of life. This factor is important e.g. in preoperative decision making regarding immediate microvascular reconstruction after e.g. mandibular resection and therefore QOL assessment should become integral component of the care of patients with OSCC. (Source: Head and Face Medicine)
Source: MedWorm: Oral Cancer
Tags: Carcinomas, cell, gender, Life, Oral, patients, quality, specific, squamous
Eruptive keratoacanthoma and squamous cell carcinoma complicating imiquimod therapy: Response to oral acitretin
(Source: Australasian Journal of Dermatology)
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Source: MedWorm: Oral Cancer
Tags: acitretin, carcinoma, cell, complicating, Eruptive, imiquimod, keratoacanthoma, Oral, response, squamous, therapy
Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions.
Authors: Qiao B, Johnson NW, Gao J
Snail and Slug play important roles in cancer progression by promoting epithelial-mesenchymal transition (EMT). Although Snail is well studied, its role in oral squamous cell carcinoma (OSCC) and its regulatory relationship with Slug remain unclear. We aimed to determine whether Snail and Slug interplay occurs in transforming growth factor-beta1 (TGF-beta1)-initiated EMT of OSCC cells, and to assess the expression of matrix metalloproteinases (MMPs) in this process. Three OSCC cell lines, SCC9, SCC15 and SCC25 were treated with recombinant TGF-beta1 for 0-6 days. Activities of the EMT regulators, Snail and Slug, and of extracellular hallmarks, MMP2 and 9, were detected using real-time PCR and Western blots. An in vitro wound healing assay then assesse…
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, correlates, epithelialmesenchymal, expressions., factorbeta1, familydependent, growth, matrix, metalloproteinase2, Oral, Snail, squamous, transforming, transition, triggered
Effects of Lentinan alone and in combination with fluoropyrimidine anticancer agent on growth of human oral squamous cell carcinoma in vitro and in vivo.
In this study, the response of human OSCC cells to Lentinan alone and in combination with S-1 was examined using nude mouse xenograft models. S-1 (6.9 mg/kg/day, 7 times/week) was administered orally and Lentinan (0.1 mg/kg/day, 2 times/week) was injected into peritumoral tissue for three weeks. Apoptotic cells were detected by a TUNEL method. The gene expression level of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) was determined using microdissection and RT-PCR, and their protein levels were determined using ELISA. Combined therapy of Lentinan and S-1 markedly exerted antitumor effects on human OSCC xenografts and significantly induced apoptotic cells in tumors treated with Lentinan plus S-1. Microdissection and RT-PCR rev…
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Source: MedWorm: Oral Cancer
Tags: Agent, Alone, Anticancer, carcinoma, cell, Combination, effects, fluoropyrimidine, growth, human, Lentinan, Oral, squamous, vitro, vivo
Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma
Conclusion : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase. (Source: Table of Contents : Indian Journal of Dental Research : 2006 – 17(3))
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Source: MedWorm: Oral Cancer
Tags: angiogenesis, carcinoma, cell, cells, evaluation, immunohistochemical, mast, Oral, squamous
Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70).
Conclusion: Therefore, these results indicate that PEA reduced the chemoresistance through inhibition of HSP70 expression and also induced apoptosis in chemoresistant YD-9 cells.
PMID: 20635445 [PubMed - in process] (Source: Yonsei Medical Journal)
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Source: MedWorm: Oral Cancer
Tags: aeruginosa, carcinoma, cell, chemoresistance, Exotoxin, Heat, HSP70., Inhibition, Oral, Proteins, Pseudomonas, reduces, Shock, squamous
Comparison between two methods for human papilomavÃrus DNA detection in lip squamous cell carcinoma
Conclusion: HPV DNA detection of lip SCC increased sixfold in the studied cases with the employment of nPCR. (Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
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Source: MedWorm: Oral Cancer
Tags: Between, carcinoma, cell, Comparison, Detection, human, methods, papilomavÃrus, squamous
Cutaneous Metastasis of Squamous Cell Carcinoma of Oral Mucosa with a Purpura-Like Appearance with Tumor Thrombosis in Lymphatic Vessels
The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
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Source: MedWorm: Oral Cancer
Tags: Appearance, carcinoma, cell, Cutaneous, Lymphatic, metastasis, Mucosa, Oral, PurpuraLike, squamous, Thrombosis, tumor, Vessels