Tag: patients
This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2006 and 2007 were enrolled in the study. The gathering of data comprised reviewing hospital files and applying the University of Washington Quality of Life (UW-QOL) questionnaire previously and 1 year after the surgery. Comparative analysis used Poisson regression to assess factors associated with survival and a paired t-test to compare preoperative and 1-year postoperative QOL ratings. RESULTS: 1 year after surgery, 7 patients were not found (dropout of the cohort); 15 had died and 25 fulfilled the UW-QOL…
Source: MedWorm: Oral Cancer
Tags: 1year, Cancer, followup, Life, Oral, oropharyngeal, patients, quality, resection, survival, tumor
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Conclusions We show here a markedly reduced docetaxel exposure followed by CYP3A induction by, most likely, dexamethasone. Peroral midazolam
seemed not to predict docetaxel exposure. Slow CYP3A-mediated metabolism might predispose patients to adverse events of docetaxel.
Content Type Journal ArticleDOI 10.1007/s00280-010-1426-6Authors
Johanna Hilli, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, 3rd floor, 20520 Turku, FinlandLiisa Sailas, Department of Oncology, Vaasa Central Hospital, Vaasa, FinlandSirkku Jyrkkiö, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandSeppo Pyrhönen, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandKari Laine, …
Source: MedWorm: Oral Cancer
Tags: Activity, Breast, Cancer, CYP3A, docetaxel, exposure, Induction, lowered, NCT01110291, patients, primary
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Abstract: The incidence and extent of pericardial involvement in neoplastic disease varies. In a considerable number of patients with breast or lung cancer or with mediastinal lymphoma, in addition to direct involvement by the tumor, radiation therapy as well as systemic tumor treatment can also lead to pericardial effusion. In addition, in immunosuppressed tumor patients, pericardial effusion can also arise from viral, bacterial, and autoimmune causes. To distinguish between these 3 different conditions leading to pericardial effusion, the diagnosis should be based on pericardiocentesis followed by fluid analysis for cytology and biomarkers, on epicardial and pericardial biopsy facilitated by flexible pericardioscopy with analysis of specimens by conventional histology and molecular biolo…
Source: MedWorm: Oral Cancer
Tags: disease, Effusion, evaluation, Management, Neoplastic, patients, Pericardial
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Conclusion These results indicated that the level of morphine-3-glucuronide is related to the patientâs perception of morphine effect,
and the plasma concentration of morphine-3-glucuronide and the ratio of morphine-3-glucuronide/morphine indicated potency
to assess clinical effect.
Content Type Journal ArticleDOI 10.1007/s11096-010-9430-9Authors
Tomoya Sakurada, Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, JapanShinya Takada, Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center, 4-2 Kikusui, Shiroishi-ku, Sapporo, Hokkaido 003-0804, JapanHisae Eguchi, Department of Pharmacy, National Hospital Organization Shikoku Cancer Center, 160 Kou, Minamiumemo…
Source: MedWorm: Oral Cancer
Tags: Between, Cancer, concentrations, metabolites, morphine, pain, patients, plasma, relationship
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Conclusions:
The data obtained within this investigation demonstrated that gender had the most significant power on the subjectively perceived postoperative quality of life. This factor is important e.g. in preoperative decision making regarding immediate microvascular reconstruction after e.g. mandibular resection and therefore QOL assessment should become integral component of the care of patients with OSCC. (Source: Head and Face Medicine)
Source: MedWorm: Oral Cancer
Tags: Carcinomas, cell, gender, Life, Oral, patients, quality, specific, squamous
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Conclusion: Esophageal pathology is extremely common in patients treated for HNCA. These findings support routine esophageal screening after HNCA treatment. (Source: Otolaryngology – Head and Neck Surgery)
Source: MedWorm: Oral Cancer
Tags: after, Cancer, esophageal, head, neck, pathology, patients, Treatment
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Conclusion The SOx regimen evidenced a relatively high response rate and was well tolerated as a first-line therapy for advanced gastric
cancer.
Content Type Journal ArticleDOI 10.1007/s10637-010-9507-2Authors
Sung Yong Oh, Department of Internal Medicine, Dong-A University College of Medicine, Busan, KoreaHyuk-Chan Kwon, Department of Internal Medicine, Dong-A University College of Medicine, Busan, KoreaSang-Ho Jeong, Departments of Surgery, Gyeongsang National University Hospital, Jinju, South KoreaYoung-Tae Joo, Departments of Surgery, Gyeongsang National University Hospital, Jinju, South KoreaYoung-Joon Lee, Departments of Surgery, Gyeongsang National University Hospital, Jinju, South KoreaSu hee Cho, Departments of Internal Medicine, Gyeongsang National University Hospital, Ji…
Source: MedWorm: Oral Cancer
Tags: Advanced, Cancer, chemotherapy., Combination, FirstLine, Gastric, oxaliplatin, patients, Phase, Study, therapy
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Summary Sunitinib is associated with a robust objective response rate in patients with metastatic clear cell renal cell carcinoma
(RCC). The primary objective of this phase II clinical trial was to assess the overall response rate for sunitinib in patients
with papillary metastatic RCC as well as other non-clear cell histologies. A Simon 2-stage design was used to determine the
number of papillary metastatic RCC patients for enrollment, and allowed for descriptive response data for other non-clear
cell histologies. Twenty-three patients were enrolled, including 8 with papillary renal cell carcinoma (RCC) and the remainder
with other non-clear cell histologies (unclassified in 5 patients). All patients received 50 mg of oral sunitinib in cycles
of 4 weeks followed…
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, Metastatic, nonclear, patients, Phase, renal, Sunitinib, Trial
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CONCLUSIONS: There is weak and unreliable evidence that low level laser treatment reduces the severity of the mucositis. Less opiate is used for PCA versus continuous infusion. Further, well designed, placebo or no treatment controlled trials assessing the effectiveness of interventions investigated in this review and new interventions for treating mucositis are needed.
PMID: 20687070 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: MedWorm: Oral Cancer
Tags: Cancer, Interventions, Mucositis, Oral, patients, Receiving, treating, Treatment
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Conclusion:
Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases. In further studies, CRP levels in precancerous lesions and in HPV positive patients with oral SCC should be studied. (Source: BioMed Central)
Source: MedWorm: Oral Cancer
Tags: Cancer, Creactive, head, Levels, marker, neck, patients, prognostic, Protein
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