In this study we performed a preliminary light and transmission electron microscopy morphological evaluation focussing in particular on keratinocyte intercellular adhesion and terminal differentiation in chronic smokers.Design: Human biopsies were obtained from healthy young chronic smoker women (n=5) compared with a parallel group of non-smoker healthy volunteers (n=5), as the smoking habit among women is ever more spreading. Samples were processed for light and transmission electron microscopy. On paraffin sections Masson’s and Dane and Herman’s histochemical staining were performed. Biomarker expressions of intercellular adhesion (desmoglein 3, Dsg3), terminal differentiation (keratin 10, K10 and keratin 14, K14), and basal membrane preservation (laminin) were investigated by immunofluo… Source: MedWorm: Oral Cancer
Tag: Oral
Desmoglein 3 and keratin 10 expressions are reduced by chronic exposure to cigarette smoke in human keratinised oral mucosa explants
Tags: Chronic, Cigarette, Desmoglein, explants, exposure, expressions., human, keratin, keratinised, Mucosa, Oral, reduced, Smoke
Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection
This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2006 and 2007 were enrolled in the study. The gathering of data comprised reviewing hospital files and applying the University of Washington Quality of Life (UW-QOL) questionnaire previously and 1 year after the surgery. Comparative analysis used Poisson regression to assess factors associated with survival and a paired t-test to compare preoperative and 1-year postoperative QOL ratings. RESULTS: 1 year after surgery, 7 patients were not found (dropout of the cohort); 15 had died and 25 fulfilled the UW-QOL…
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Source: MedWorm: Oral Cancer
Tags: 1year, Cancer, followup, Life, Oral, oropharyngeal, patients, quality, resection, survival, tumor
About Face: Oral Bisphosphonates Linked to Esophageal Cancer
As a new study reports a link, in direct contrast to a previous recent study, experts emphasize that patients need to be reminded about how to take these drugs. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines) Source: MedWorm: Oral Cancer
Tags: About, Bisphosphonates, Cancer, esophageal, Face, linked, Oral
Long term use of oral bisphosphonates may double risk of esophageal cancer, study finds
People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing esophageal cancer (cancer of the gullet), according to a new study. (Source: ScienceDaily Headlines)
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Source: MedWorm: Oral Cancer
Tags: Bisphosphonates, Cancer, double, esophageal, finds, long, Oral, risk, Study, term
Circadian Expression of Clock- and Tumor Suppressor Genes in Human Oral Mucosa.
Conclusion: Our study revealed a proper circadian regulation profile of several clock- and tumor suppressor genes at defined points in time in the participants studied. These findings could provide important information regarding genes displaying the same expression profile in the gastrointestinal tract amounting to a physiological expression profile of healthy humans. In the future asynchronous regulations of those genes might be an additional assistant method to detect derivations distinguishing normal from malignant tissue or assessing risk factors for cancer.
PMID: 20798499 [PubMed - as supplied by publisher] (Source: Cancer Control)
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Source: MedWorm: Oral Cancer
Tags: Circadian, Clock, expression, Genes, human, Mucosa, Oral, Suppressor, tumor
Prevention: Oral bisphosphonate use may protect women from breast cancer
Nature Reviews Clinical Oncology 7, 482 (2010). doi:10.1038/nrclinonc.2010.126
Author: Rebecca Kirk
Bisphosphonates are commonly prescribed for the treatment of osteoporosis and for the prevention of cancer-induced bone loss. Interest in the potential of bisphosphonates for the prevention of cancer was sparked by a publication last year by Michael Gnant and coworkers. They reported that intravenous adjuvant (Source: Nature Clinical Practice Oncology)
Source: MedWorm: Oral Cancer
Tags: bisphosphonate, Breast, Cancer, Oral, Prevention, Protect, Women
Younger Adults with Oral Cavity Squamous Cell Cancer have a Significantly Higher 5-Year Survival Rate than do Older Adults in the United States, Controlling for Patient- and Disease-Specific Characteristics
Article Title and Bibliographic Information: Age as a determinant of outcomes for patients with oral cancer.Goldenberg D, Brooksby C, et al.Oral Oncol 2009;45(8):e57-61.Reviewer: Mark D. Macek, DDS, DrPHPurpose/Question: How does 5-year survival rate for oral cavity squamous cell cancer compare for older and younger adults in the United States, using 4 specific age thresholds and controlling for sex, race, cancer site, and stage of disease?Source of Funding: Information not availableType of Study/Design: Retrospective cohort studyLevel of Evidence: Level 2: Limited quality, patient-oriented evidenceStrength of Recommendation Grade: Not applicable (Source: The Journal of Evidence-Based Dental Practice) Source: MedWorm: Oral Cancer
Tags: 5year, Adults, Cancer, Cavity, cell, Characteristics, Controlling, DiseaseSpecific, Higher, in the, Older, Oral, Patient, Rate, Significantly, squamous, States, survival, than, United, Younger
Premalignant nature of oral and vulval lichen planus: Facts and controversies
Abstract: Although many classifications include oral lesions of lichen planus in the category of a premalignant condition, there is still much discussion about whether the mucous membranes lesions should be characterized as an intrinsically premalignant condition or merely as a facilitator of the action of a carcinogenic factor. The possibility that an epidermoid carcinoma can emerge at the site of lichen planus lesions, mainly in mucous membranes, has been shown; however, several published cases omit information about other potential risk factors. This prevents a complete analysis of the triggering relationship between lichen planus and squamous cell carcinoma. This contribution reviews the literature on this subject. The question of whether oral or vulval lichen planus, or both, are prem…
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Source: MedWorm: Oral Cancer
Tags: controversies, Facts, lichen, nature, Oral, planus, premalignant, vulval
Oral chelation: Should it be used with young children?
Abstract (Source: Pediatric Blood and Cancer)
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Source: MedWorm: Oral Cancer
Oral bisphosphonates not linked to oesophageal cancer risk
(Source: Reactions) Source: MedWorm: Oral Cancer
Tags: Bisphosphonates, Cancer, linked, oesophageal, Oral, risk