Article Title and Bibliographic Information: Age as a determinant of outcomes for patients with oral cancer.Goldenberg D, Brooksby C, et al.Oral Oncol 2009;45(8):e57-61.Reviewer: Mark D. Macek, DDS, DrPHPurpose/Question: How does 5-year survival rate for oral cavity squamous cell cancer compare for older and younger adults in the United States, using 4 specific age thresholds and controlling for sex, race, cancer site, and stage of disease?Source of Funding: Information not availableType of Study/Design: Retrospective cohort studyLevel of Evidence: Level 2: Limited quality, patient-oriented evidenceStrength of Recommendation Grade: Not applicable (Source: The Journal of Evidence-Based Dental Practice) Source: MedWorm: Oral Cancer
Tag: cell
Younger Adults with Oral Cavity Squamous Cell Cancer have a Significantly Higher 5-Year Survival Rate than do Older Adults in the United States, Controlling for Patient- and Disease-Specific Characteristics
Tags: 5year, Adults, Cancer, Cavity, cell, Characteristics, Controlling, DiseaseSpecific, Higher, in the, Older, Oral, Patient, Rate, Significantly, squamous, States, survival, than, United, Younger
ORIGINAL ARTICLE: Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue
(Source: Oral Diseases)
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Source: MedWorm: Oral Cancer
Tags: Article, carcinoma, cell, cyclophilin, expression, increased, Original, peroxiredoxin, squamous, tongue
Gender specific quality of life in patients with oral squamous cell carcinomas
Conclusions:
The data obtained within this investigation demonstrated that gender had the most significant power on the subjectively perceived postoperative quality of life. This factor is important e.g. in preoperative decision making regarding immediate microvascular reconstruction after e.g. mandibular resection and therefore QOL assessment should become integral component of the care of patients with OSCC. (Source: Head and Face Medicine)
Source: MedWorm: Oral Cancer
Tags: Carcinomas, cell, gender, Life, Oral, patients, quality, specific, squamous
Eruptive keratoacanthoma and squamous cell carcinoma complicating imiquimod therapy: Response to oral acitretin
(Source: Australasian Journal of Dermatology)
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Source: MedWorm: Oral Cancer
Tags: acitretin, carcinoma, cell, complicating, Eruptive, imiquimod, keratoacanthoma, Oral, response, squamous, therapy
Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma
Summary Sunitinib is associated with a robust objective response rate in patients with metastatic clear cell renal cell carcinoma
(RCC). The primary objective of this phase II clinical trial was to assess the overall response rate for sunitinib in patients
with papillary metastatic RCC as well as other non-clear cell histologies. A Simon 2-stage design was used to determine the
number of papillary metastatic RCC patients for enrollment, and allowed for descriptive response data for other non-clear
cell histologies. Twenty-three patients were enrolled, including 8 with papillary renal cell carcinoma (RCC) and the remainder
with other non-clear cell histologies (unclassified in 5 patients). All patients received 50 mg of oral sunitinib in cycles
of 4 weeks followed…
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Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, Metastatic, nonclear, patients, Phase, renal, Sunitinib, Trial
An Update On Targeted Therapy In Metastatic Renal Cell Carcinoma
UroToday.com – For many years the mainstay of treatment for metastatic renal cell carcinoma (RCC) was immunotherapy, with response rates of from 10% to 20%. An improved understanding of the molecular biology in RCC has led to the development of numerous targeted therapies. However, to date the best therapy has not yet been validated, but sequential and combination treatment appears promising. Sunitinib, an oral inhibitor of receptor tyrosine kinases, should be considered first or second-line treatment for patients with favourable and intermediate MSKCC risk-score… (Source: Health News from Medical News Today)
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Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, Metastatic, renal, Targeted, therapy, Update.
Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions.
Authors: Qiao B, Johnson NW, Gao J
Snail and Slug play important roles in cancer progression by promoting epithelial-mesenchymal transition (EMT). Although Snail is well studied, its role in oral squamous cell carcinoma (OSCC) and its regulatory relationship with Slug remain unclear. We aimed to determine whether Snail and Slug interplay occurs in transforming growth factor-beta1 (TGF-beta1)-initiated EMT of OSCC cells, and to assess the expression of matrix metalloproteinases (MMPs) in this process. Three OSCC cell lines, SCC9, SCC15 and SCC25 were treated with recombinant TGF-beta1 for 0-6 days. Activities of the EMT regulators, Snail and Slug, and of extracellular hallmarks, MMP2 and 9, were detected using real-time PCR and Western blots. An in vitro wound healing assay then assesse…
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, correlates, epithelialmesenchymal, expressions., factorbeta1, familydependent, growth, matrix, metalloproteinase2, Oral, Snail, squamous, transforming, transition, triggered
Effects of Lentinan alone and in combination with fluoropyrimidine anticancer agent on growth of human oral squamous cell carcinoma in vitro and in vivo.
In this study, the response of human OSCC cells to Lentinan alone and in combination with S-1 was examined using nude mouse xenograft models. S-1 (6.9 mg/kg/day, 7 times/week) was administered orally and Lentinan (0.1 mg/kg/day, 2 times/week) was injected into peritumoral tissue for three weeks. Apoptotic cells were detected by a TUNEL method. The gene expression level of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) was determined using microdissection and RT-PCR, and their protein levels were determined using ELISA. Combined therapy of Lentinan and S-1 markedly exerted antitumor effects on human OSCC xenografts and significantly induced apoptotic cells in tumors treated with Lentinan plus S-1. Microdissection and RT-PCR rev…
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Source: MedWorm: Oral Cancer
Tags: Agent, Alone, Anticancer, carcinoma, cell, Combination, effects, fluoropyrimidine, growth, human, Lentinan, Oral, squamous, vitro, vivo
Multiple keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome having distinct PTCH1 mutations: a case report
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder characterized by developmental abnormalities and a predisposition to cancers. Although multiple jaw tumors, such as keratocystic odontogenic tumors (KCOTs), are one of the most frequent complications in NBCCS, the molecular mechanism for how KCOTs develop in NBCCS is poorly understood. A 15-year-old girl with 2 jaw tumors was diagnosed as NBCCS according to the clinical criteria. The pathologic findings indicated that the 2 tumors were consistent with KCOTs. A PTCH1 mutation, c.1472delT, was detected in her peripheral blood as well as in the 2 tumors. Interestingly, an additional PTCH1 mutation, c.264_265insAATA, that was not present in the peripheral blood, was found in the maxillary tumor but not the mandi… Source: MedWorm: Oral Cancer
Tags: associated, Basal, carcinoma, case, cell, distinct, having, keratocystic, Multiple, mutations, Nevoid, odontogenic, PTCH1, Report, syndrome, Tumors
Cinnamon extract induces tumor cell death through inhibition of NFkB and AP1
Conclusion:
Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFB and AP1 activities and their target genes in vitro and in vivo mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers. (Source: BMC Cancer)
Source: MedWorm: Oral Cancer
Tags: cell, Cinnamon, death, extract, induces, Inhibition, NFkB, through, tumor