Tag: carcinoma
Authors: Dank M
Primary hepatocellular cancer is the fifth most common solid tumor worldwide. Its incidence is the highest in the Third World, however, a risen incidence has been observed recently also in developed countries, due to increasing migration. In Asia and Africa the main etiological factor for HCC is chronic HBV infection, whereas in the Western world HCV etiology predominates. Additional increase in HCC incidence is expected as a consequence of climate change, since risk of aflatoxin contamination in agricultural products increases with hot and dry growing conditions. Aflatoxins are the most potent hepatocarcinogens in nature; therefore minimization of aflatoxin exposition will be a main task of food security in the future. The majority of HCC patients are diagnosed in adva…
Source: MedWorm: Oral Cancer
Tags: carcinoma, hepatocellular, primary, Treatment
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(Source: Australasian Journal of Dermatology)
Source: MedWorm: Oral Cancer
Tags: acitretin, carcinoma, cell, complicating, Eruptive, imiquimod, keratoacanthoma, Oral, response, squamous, therapy
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Summary Sunitinib is associated with a robust objective response rate in patients with metastatic clear cell renal cell carcinoma
(RCC). The primary objective of this phase II clinical trial was to assess the overall response rate for sunitinib in patients
with papillary metastatic RCC as well as other non-clear cell histologies. A Simon 2-stage design was used to determine the
number of papillary metastatic RCC patients for enrollment, and allowed for descriptive response data for other non-clear
cell histologies. Twenty-three patients were enrolled, including 8 with papillary renal cell carcinoma (RCC) and the remainder
with other non-clear cell histologies (unclassified in 5 patients). All patients received 50 mg of oral sunitinib in cycles
of 4 weeks followed…
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, Metastatic, nonclear, patients, Phase, renal, Sunitinib, Trial
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UroToday.com – For many years the mainstay of treatment for metastatic renal cell carcinoma (RCC) was immunotherapy, with response rates of from 10% to 20%. An improved understanding of the molecular biology in RCC has led to the development of numerous targeted therapies. However, to date the best therapy has not yet been validated, but sequential and combination treatment appears promising. Sunitinib, an oral inhibitor of receptor tyrosine kinases, should be considered first or second-line treatment for patients with favourable and intermediate MSKCC risk-score… (Source: Health News from Medical News Today)
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, Metastatic, renal, Targeted, therapy, Update.
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Authors: Qiao B, Johnson NW, Gao J
Snail and Slug play important roles in cancer progression by promoting epithelial-mesenchymal transition (EMT). Although Snail is well studied, its role in oral squamous cell carcinoma (OSCC) and its regulatory relationship with Slug remain unclear. We aimed to determine whether Snail and Slug interplay occurs in transforming growth factor-beta1 (TGF-beta1)-initiated EMT of OSCC cells, and to assess the expression of matrix metalloproteinases (MMPs) in this process. Three OSCC cell lines, SCC9, SCC15 and SCC25 were treated with recombinant TGF-beta1 for 0-6 days. Activities of the EMT regulators, Snail and Slug, and of extracellular hallmarks, MMP2 and 9, were detected using real-time PCR and Western blots. An in vitro wound healing assay then assesse…
Source: MedWorm: Oral Cancer
Tags: carcinoma, cell, correlates, epithelialmesenchymal, expressions., factorbeta1, familydependent, growth, matrix, metalloproteinase2, Oral, Snail, squamous, transforming, transition, triggered
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In this study, the response of human OSCC cells to Lentinan alone and in combination with S-1 was examined using nude mouse xenograft models. S-1 (6.9 mg/kg/day, 7 times/week) was administered orally and Lentinan (0.1 mg/kg/day, 2 times/week) was injected into peritumoral tissue for three weeks. Apoptotic cells were detected by a TUNEL method. The gene expression level of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) was determined using microdissection and RT-PCR, and their protein levels were determined using ELISA. Combined therapy of Lentinan and S-1 markedly exerted antitumor effects on human OSCC xenografts and significantly induced apoptotic cells in tumors treated with Lentinan plus S-1. Microdissection and RT-PCR rev…
Source: MedWorm: Oral Cancer
Tags: Agent, Alone, Anticancer, carcinoma, cell, Combination, effects, fluoropyrimidine, growth, human, Lentinan, Oral, squamous, vitro, vivo
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Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder characterized by developmental abnormalities and a predisposition to cancers. Although multiple jaw tumors, such as keratocystic odontogenic tumors (KCOTs), are one of the most frequent complications in NBCCS, the molecular mechanism for how KCOTs develop in NBCCS is poorly understood. A 15-year-old girl with 2 jaw tumors was diagnosed as NBCCS according to the clinical criteria. The pathologic findings indicated that the 2 tumors were consistent with KCOTs. A PTCH1 mutation, c.1472delT, was detected in her peripheral blood as well as in the 2 tumors. Interestingly, an additional PTCH1 mutation, c.264_265insAATA, that was not present in the peripheral blood, was found in the maxillary tumor but not the mandi…
Source: MedWorm: Oral Cancer
Tags: associated, Basal, carcinoma, case, cell, distinct, having, keratocystic, Multiple, mutations, Nevoid, odontogenic, PTCH1, Report, syndrome, Tumors
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We report the clinical and pathologic features of an intraoral sebaceous carcinoma and review the literature. The intraoral buccal mucosal tumor from a 50-year-old man was a poorly differentiated carcinoma with sebaceous differentiation and expression of androgen receptor. Fordyce granules and a minor salivary gland with a duct were identified in vicinity to the tumor. We discuss the differential diagnosis and histogenesis. The patient underwent surgery and adjuvant radiation therapy. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: MedWorm: Oral Cancer
Tags: carcinoma, case, Cavity, literature, Oral, Report, Review, Sebaceous
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Conclusion : These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase. (Source: Table of Contents : Indian Journal of Dental Research : 2006 – 17(3))
Source: MedWorm: Oral Cancer
Tags: angiogenesis, carcinoma, cell, cells, evaluation, immunohistochemical, mast, Oral, squamous
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