Conclusions:
Our in vitro and in vivo data support PGG as a potential drug candidate for breast cancer with novel targeting actions, especially for a triple negative BCa xenograft model. (Source: Breast Cancer Research)
Source: MedWorm: Oral Cancer
Tag: Breast
Penta-O-galloyl-beta-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
Tags: Active, Against, arrest, Breast, Cancer, cells, cyclindependent, growth, human, independently, induces, Inhibitor, Kinase, Negative, Orally, PentaOgalloylbetaDglucose, replicative, Sphase, Triple, xenograft
NCT01110291: induction of CYP3A activity and lowered exposure to docetaxel in patients with primary breast cancer
Conclusions We show here a markedly reduced docetaxel exposure followed by CYP3A induction by, most likely, dexamethasone. Peroral midazolam
seemed not to predict docetaxel exposure. Slow CYP3A-mediated metabolism might predispose patients to adverse events of docetaxel.
Content Type Journal ArticleDOI 10.1007/s00280-010-1426-6Authors
Johanna Hilli, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, 3rd floor, 20520 Turku, FinlandLiisa Sailas, Department of Oncology, Vaasa Central Hospital, Vaasa, FinlandSirkku Jyrkkiö, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandSeppo Pyrhönen, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandKari Laine, …
Source: MedWorm: Oral Cancer
Tags: Activity, Breast, Cancer, CYP3A, docetaxel, exposure, Induction, lowered, NCT01110291, patients, primary
Prevention: Oral bisphosphonate use may protect women from breast cancer
Nature Reviews Clinical Oncology 7, 482 (2010). doi:10.1038/nrclinonc.2010.126
Author: Rebecca Kirk
Bisphosphonates are commonly prescribed for the treatment of osteoporosis and for the prevention of cancer-induced bone loss. Interest in the potential of bisphosphonates for the prevention of cancer was sparked by a publication last year by Michael Gnant and coworkers. They reported that intravenous adjuvant (Source: Nature Clinical Practice Oncology)
Source: MedWorm: Oral Cancer
Tags: bisphosphonate, Breast, Cancer, Oral, Prevention, Protect, Women
Oral contraceptives increase breast cancer risk in African-American women
Oral contraceptive formulations used in recent decades increase the risk for breast cancer in African-American women, with a greater effect for estrogen receptor-negative than positive cancer, US study data show. (Source: MedWire News – Oncology) Source: MedWorm: Oral Cancer
Tags: AfricanAmerican, Breast, Cancer, contraceptives, increase, Oral, risk, Women
The pill may increase breast cancer risk
BOSTON, Aug. 5 (UPI) — A study involving African-American women found those who used oral contraceptives had an increased risk of getting breast cancer, U.S. researchers say.
Breast cancer – United States – Cancer – African American – Breast (Source: Health News – UPI.com) Source: MedWorm: Oral Cancer
Oral contraceptive use associated with increased risk of breast cancer in African-American women, study finds
Researchers have reported that African-American women who use oral contraceptives have a greater likelihood of developing breast cancer than nonusers. The study results were based on data from the Black Women’s Health Study, a large follow-up study of 59,000 African-American women from across the US conducted by investigators at the Slone Epidemiology Center since 1995. (Source: ScienceDaily Headlines)
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Source: MedWorm: Oral Cancer
Tags: AfricanAmerican, associated, Breast, Cancer, Contraceptive, finds, increased, Oral, risk, Study, Women
African Ancestry Linked to Triple-Negative Breast Cancer
The FDA has approved glycopyrrolate oral solution for the treatment of patients aged 3 to 16 years with chronic severe drooling associated with neurologic conditions, such as cerebral palsy. Medscape Medical News (Source: Medscape Today Headlines)
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Source: MedWorm: Oral Cancer
Tags: African, Ancestry, Breast, Cancer, linked, TripleNegative
Bisphosphonates for Osteoporosis Reduce Risk for Breast Cancer
Two retrospective studies suggesting that postmenopausal women who take oral bisphosphonates for osteoporosis have a reduced risk for breast cancer have now been published. Medscape Medical News (Source: Medscape Today Headlines)
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Source: MedWorm: Oral Cancer
Tags: Bisphosphonates, Breast, Cancer, Osteoporosis, Reduce, risk
Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast
We describe a patient with SLS as a paraneoplastic manifestation of breast carcinoma, in whom GAD-Ab was present. The patient responded very well to oral diazepam, baclofen and steroids.This is the third reported case of SLS as a paraneoplastic accompaniment to cancer. (Source: Neurology India) Source: MedWorm: Oral Cancer
Tags: Acid, antibodypositive, associated, Breast, carcinoma, decarboxylase, Glutamic, limb, paraneoplastic, stiff, syndrome
Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory Analysis From the ATAC Trial [Breast Cancer]
Conclusion
These results confirm the poorer prognosis of obese women with early-stage breast cancer. Recurrence rates were lower for anastrozole than tamoxifen for all BMI quintiles. Our results suggest that the relative efficacy of anastrozole compared to tamoxifen is greater in thin postmenopausal women and higher doses or more complete inhibitors might be more effective in overweight women, but this requires independent confirmation. (Source: Journal of Clinical Oncology)
Source: MedWorm: Oral Cancer
Tags: analysis, Anastrozole, ATAC, body, Breast, Cancer, effect, exploratory, index, mass, Recurrences, Tamoxifen, treated, Trial, Women