Conclusion
These results confirm the poorer prognosis of obese women with early-stage breast cancer. Recurrence rates were lower for anastrozole than tamoxifen for all BMI quintiles. Our results suggest that the relative efficacy of anastrozole compared to tamoxifen is greater in thin postmenopausal women and higher doses or more complete inhibitors might be more effective in overweight women, but this requires independent confirmation. (Source: Journal of Clinical Oncology)
Source: MedWorm: Oral Cancer
Tag: analysis
Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory Analysis From the ATAC Trial [Breast Cancer]
Tags: analysis, Anastrozole, ATAC, body, Breast, Cancer, effect, exploratory, index, mass, Recurrences, Tamoxifen, treated, Trial, Women
Discrepancy of the Effects of Zinc Supplementation on the Prevention of Radiotherapy-Induced Mucositis Between Patients With Nasopharyngeal Carcinoma and Those With Oral Cancers: Subgroup Analysis of a Double-Blind, Randomized Study
(Source: Nutrition and Cancer)
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Source: MedWorm: Oral Cancer
Tags: analysis, Between, cancers, carcinoma, Discrepancy, doubleblind, effects, Mucositis, nasopharyngeal, Oral, patients, Prevention, RadiotherapyInduced, randomized, Study, Subgroup, Supplementation, Those, Zinc
Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
Conclusions:
Genes exhibiting CNA-correlated expression may have biological impact on carcinogenesis and cancer progression in OSCC. Determination of copy number-associated transcripts associated with clinical outcomes in tumor cells with an aggressive phenotype (i.e., cells metastasized to the lymph nodes) can help prioritize candidate transcripts from high-throughput data for further studies. (Source: Molecular Cancer)
Source: MedWorm: Oral Cancer
Tags: analysis, associated, carcinoma, cell, copy, expression, gene, Genes, Identifies, Integrative, Metastatic, number, Oral, Poor, squamous, survival
Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis
Conclusion:
The combination of docetaxel and S-1 had good clinical activity with acceptable toxicity in patients with advanced or recurrent gastric cancer. (Source: World Journal of Surgical Oncology)
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Source: MedWorm: Oral Cancer
Tags: Advanced, analysis, Cancer, Combination, docetaxel, FirstLine, Gastric, patients, recurrent, retrospective, therapy, Treatment
Actinic lesions in fishermen’s lower lip: clinical, cytopathological and histopathologic analysis
CONCLUSION: The cytologic analysis was not useful for detecting epithelial dysplasia or malignant alterations. (Source: Clinics)
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Source: MedWorm: Oral Cancer
Tags: Actinic, analysis, Clinical, cytopathological, fishermen's, histopathologic, lesions, lower
Comparative analysis of the immunohistochemistry expression of p27, p21WAF/Cip1, and p16INK4a in oral normal epithelium, squamous papilloma and squamous cell carcinoma
CONCLUSIONS: The study revealed a statistically significant difference for p27 expression when comparing the control and oral squamous papilloma groups with the oral squamous cell carcinoma group. p21WAF/Cip1 did not prove to be useful to differentiate the groups. p16INK4a showed diffuse immunopositivity in a minority of the oral squamous cell carcinoma cases. The oral squamous papilloma group behaved similarly to the control group as to the three markers. (Source: Jornal Brasileiro de Patologia e Medicina Laboratorial) Source: MedWorm: Oral Cancer
Tags: analysis, carcinoma, cell, Comparative, epithelium, expression, immunohistochemistry, normal, Oral, p16INK4a, p21WAF/Cip1, papilloma, squamous
Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: dosimetric analysis incorporating quality assurance guidelines from RTOG 0225.
Authors: Chen AM, Lee NY, Yang CC, Liu T, Narayan S, Vijayakumar S, Purdy JA
Intensity-modulated radiotherapy (IMRT) treatment plans generated by segmental multileaf collimator (SMLC) and helical tomotherapy (HT) techniques for patients with nasopharyngeal carcinoma were compared using standardized criteria proposed by Radiation Therapy Oncology Group (RTOG) protocol 0225. The goal was to deliver a prescribed dose of 70 Gy to at least 95% of the planning target volume (PTV) encompassing gross tumor, and 59.4 Gy and 50.4 Gy, respectively, to areas at high and low risk for microscopic disease, over 33 treatments while respecting constraints to organs at risk (OAR). HT-IMRT significantly reduced dose to the contralateral parotid gland and improved dose homogeneity to the PTVs. Mean doses …
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Source: MedWorm: Oral Cancer
Tags: 0225., analysis, assurance, carcinoma, collimatorbased, Comparison, dosimetric, guidelines, helical, incorporating, intensitymodulated, multileaf, nasopharyngeal, quality, Radiotherapy, RTOG, segmental, Techniques, tomotherapy, Using
Treatment of thoracic actinomycosis: A retrospective analysis of 40 patients
Conclusions : Medical treatment failure is possible in patients with thoracic actinomycosis, and close monitoring is necessary in those who begin antibiotic therapy. In addition, surgical resection may be a valid option for patients who do not respond to antibiotic therapy, with the consideration of the age and comorbid conditions. (Source: Annals of Thoracic Medicine)
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Source: MedWorm: Oral Cancer
Tags: actinomycosis, analysis, patients, retrospective, thoracic, Treatment
Multivariate analysis of the influence of patient-, tumor-, and management-related factors on the outcome of surgical therapy for facial basal-cell carcinoma
Conclusions The identified negative predictors of treatment outcome should be included in the informed consent to objectify the patient’s
preoperative expectations.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10006-010-0215-zAuthors
Cornelia Katharina Mueller, University of Jena Department of Oral and Maxillofacial Surgery/ Plastic Surgery Erlanger Allee 101 07747 Jena GermanyKristin Nicolaus, University of Jena Department of Oral and Maxillofacial Surgery/ Plastic Surgery Erlanger Allee 101 07747 Jena GermanyMichael Thorwarth, University of Jena Department of Oral and Maxillofacial Surgery/ Plastic Surgery Erlanger Allee 101 07747 Jena GermanyStefan Schultze-Mosgau, University of Jena Department of Oral and Maxillofacial Surgery/ Plastic Surger…
Source: MedWorm: Oral Cancer
Tags: analysis, basalcell, carcinoma, facial, factors, influence, managementrelated, Multivariate, outcome, Patient, Surgical, therapy, tumor
Oral cancer study shows full tumor genome; novel method speeds analysis for individualized medicine
Researchers are reporting on the application of a new approach for sequencing RNA to study cancer tumors. (Source: ScienceDaily Headlines)
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Source: MedWorm: Oral Cancer
Tags: analysis, Cancer, full, genome, individualized, medicine, method, Novel, Oral, shows, Speeds, Study, tumor