People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing esophageal cancer (cancer of the gullet), according to a new study. (Source: ScienceDaily Headlines)
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Source: MedWorm: Oral Cancer
Tags: Bisphosphonates, Cancer, double, esophageal, finds, long, Oral, risk, Study, term
Conclusions:
Our in vitro and in vivo data support PGG as a potential drug candidate for breast cancer with novel targeting actions, especially for a triple negative BCa xenograft model. (Source: Breast Cancer Research)
Source: MedWorm: Oral Cancer
Tags: Active, Against, arrest, Breast, Cancer, cells, cyclindependent, growth, human, independently, induces, Inhibitor, Kinase, Negative, Orally, PentaOgalloylbetaDglucose, replicative, Sphase, Triple, xenograft
Applying sunscreen has become a necessity now-a-days. A burn can give you terrible side effects. Know how to select the right sunscreen to protect your skin during any activity. This is how.
Be smart – use sunblock. Perhaps you remember the past when it was alright to go outside with no sunblock. However, researchers say the sun’s rays are harsher now than even a decade back. Spending time outdoors without protecting your skin is unhealthy. Please be aware that sunscreen oils and tanning lotions having an SPF of 2 or less are absolutely ineffective for protection from the sun. They are unhealthy and might even cause skin cancer. Go ahead and ask yourself if you believe a tan is really worth your life, hopefully you’ll soon see the need to pick the correct sunblock.
The minimum sunblock rating should be SPF 15, for sufficient protection. You need to choose at least an SPF 15, no matter what activity you’ll doing outside. This sunscreen protects your skin minimally; at least apply it. Read on to see if you’ll need more than this basic SPF 15 sunscreen because different activities and durations outdoors require different sunscreens.
Go for an SPF of 30 if your skin is light. If you are an outdoor person at least for some time of the day, and your skin is light or fair-colored, the most effective sunscreen for you should be at least an SPF 30. You skin may burn easily and this will prevent it.
This is very important for people facing a high risk of skin cancer.
Make sure you pick a sunscreen with both UVA and UVB protection. Make sure to get the best sunscreen that blocks and/or protects you from both Ultraviolet A (UVA) and Ultraviolet B (UVB) rays. UVB rays can be protected by the SPF rating and premature skin aging and wrinkles can be prevented by UVA. Choose a sunscreen with both these elements.
If necessary, use waterproof. If you’re doing things in water (or perspire a lot), choose a waterproof (not water-resistant) sunblock. This type of sunscreen has a special formula to hold its protective qualities up to an hour and a half of being in water. You must continue to reapply sunscreen more often if you are going to be in water. Even waterproof sunscreen doesn’t stay on that long and needs to be reapplied after about an hour.
Sunscreen must be applied frequently and at the earliest possible time. Once you have selected the correct sunscreen, apply it about a half hour before going out in the sun so that it works correctly. Apply sunscreen in advance of going outdoors because it needs to be absorbed by your skin before it can work properly. And re-apply sunscreen often when outside, no matter whether it’s sunny or cloudy. It will lose its strength in time even if it is the right sunscreen. Put on sunblock throughout the day and don’t underestimate the importance of doing so.
Remember to apply lip balm! Protecting the lips is often forgotten by people. The SPF rating of the lip protection you apply should be at least 15. Your lips are no different from the skin on the rest of your face when it comes to the possibility of damage from the harsh sunlight. Your lip region needs sun protection, too, so use a product with an SPF rating of at least 15.
There is an expiration date for any sunblock, as is usually the case with body care products. Check the expiry date on your sunscreen often to make sure that your skin continues to be protected from harmful rays of the sun.
Tiffany Provost writes about Skin and Personal Care for HowToDoThings.com.
Authors: Dank M
Primary hepatocellular cancer is the fifth most common solid tumor worldwide. Its incidence is the highest in the Third World, however, a risen incidence has been observed recently also in developed countries, due to increasing migration. In Asia and Africa the main etiological factor for HCC is chronic HBV infection, whereas in the Western world HCV etiology predominates. Additional increase in HCC incidence is expected as a consequence of climate change, since risk of aflatoxin contamination in agricultural products increases with hot and dry growing conditions. Aflatoxins are the most potent hepatocarcinogens in nature; therefore minimization of aflatoxin exposition will be a main task of food security in the future. The majority of HCC patients are diagnosed in adva…
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Source: MedWorm: Oral Cancer
Tags: carcinoma, hepatocellular, primary, Treatment
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Whether your look is “jungle chic”, “innocent chic” or “sexy chic”, we have the hair straightener for you at the lowest prices.
Tags: hair, join, religion, straighteners
“In the last year alone I have convinced myself I have had oral cancer, breast cancer and a rare nerve disorder. (Source: Scotsman.com News – Health)
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Source: MedWorm: Oral Cancer
Tags: conclusion', jump, Most, nightmarish, You'
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Conclusions We show here a markedly reduced docetaxel exposure followed by CYP3A induction by, most likely, dexamethasone. Peroral midazolam
seemed not to predict docetaxel exposure. Slow CYP3A-mediated metabolism might predispose patients to adverse events of docetaxel.
Content Type Journal ArticleDOI 10.1007/s00280-010-1426-6Authors
Johanna Hilli, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, 3rd floor, 20520 Turku, FinlandLiisa Sailas, Department of Oncology, Vaasa Central Hospital, Vaasa, FinlandSirkku Jyrkkiö, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandSeppo Pyrhönen, Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandKari Laine, …
Source: MedWorm: Oral Cancer
Tags: Activity, Breast, Cancer, CYP3A, docetaxel, exposure, Induction, lowered, NCT01110291, patients, primary
Radium, a radioactive alkaline-earth element in Group 2 (IIA) and Row 7 of the periodic table, was discovered in 1898 by Marie Curie and her husband, Pierre Curie. It was found in an ore of uranium called pitchblende. The alkaline earth metals also include beryllium, magnesium, calcium, strontium, and barium. Radium is luminescent, meaning thereby that it gives off radiation that can be seen in the dark. Because of its radiation, however, it has relatively few uses.
The discovery of radium is one of the most interesting stories in science. The story has been told over and over again in books, articles, and motion pictures, and on television. The story begins with the research of French physicist Antoine-Henri who in 1896, made a discovery about the ore called pitchblende that contains the element uranium. Becquerel found that pitchblende gives off radiation that acts much like light. The main difference is that the radiation from pitchblende is not visible to the human eye.
Becquerel’s discovery caused great excitement among scientists. Many physicists stopped their own research and began to study this new curiosity. One of those who did so was a graduate student named Marie Sklodowska Curie. Marie had been born in Warsaw, Poland, as Marya Sklodowska. In 1891, she moved to Paris, France, to study physics. Three years later she met another physicist, Pierre Curie to whom she married in 1895.
Marie and Pierre were especially interested in learning more about pitchblende. What was in the ore that was giving off radiation, they asked to themselves. To answer this question, they purified huge amounts of the natural ore. Eventually, they isolated a new element that gave off radiation much more intensely than did the pitchblende itself. The Curies named the new element polonium after Poland, Curie’s homeland. But they were not finished with their research. They thought at least one other element might be in the pitchblende. So they continued the process of purification and in 1898, they isolated a second new element that hey called the element radium. They chose this name because the element gives off such intense radiation. It took the Curies another four years to prepare one gram of this element. To do so, they had to sift through more than seven metric tons of pitchblende.
With a melting point of 700°C (1,300°F), a boiling point of 1,737°C (3,159°F), and density of 5.5 grams per cubic centimeter, the brilliant white metal radium, was once used in paint that was applied on the hands and numbers of clocks and watches. The visible radiation it emitted made it possible to read the numbers in the dark. But the radiation proved very harmful to people who applied the radium paint to a watch or clock.
The technique they used was to make a sharp point on their brushes by twirling the brush between their lips. They then dipped the brush into radioactive radium paint. The dipping and twirling sequence ultimately caused the painters to get a lot of radium on their lips. This resulted in many cases of lip and mouth cancer among those painters. So radium is no longer used on clocks and watches.
Radium combines with most non-metals, including oxygen, fluorine, chlorine, and nitrogen. It also reacts with acids with the formation of hydrogen gas. Radium’s chemical properties are of much less interest than its radioactivity, however. The amount of radium in the Earth’s crust is very small. Its abundance has been estimated to be about 0.0000001 parts per million. It occurs not only in pitchblende, but in all ores that contain uranium. It is formed when uranium gives off radiation and breaks down.
Four naturally occurring isotopes of radium: radium-223, radium-224, radium-226, and radium-228are known. But only radium-226 has any commercial applications. It has a half life of 1,620 years. The other three isotopes have half lives of only a few days or years. These short half lives make it difficult to work with the isotopes. The only isotope now used very often, radium-226, is generally not used directly. Instead, it is used to make radon gas. Radon gas is one of the products formed when radium breaks down. The radon gas is easier and safer to work with than is the radium itself. The process by which radium is obtained is similar to that used by the Curies. The metal is separated from other substances found in pitchblende by a long series of chemical reactions.
Because of its history, radium is a very interesting and important element. But radium and its compounds have relatively few uses. In fact, no more than about two kilograms (five pounds) of radium is made each year. The small amount of radium that is available is used for medical purposes. The radium is used to produce radon gas which, in turn, is used to treat cancer. Radiation given off by radium is sometimes used also to study the composition of metals, plastics, and other materials. Like all radioactive materials, radium is a dangerous substance to handle. The radiation it gives off can kill living cells. This property is desirable in treating cancer. Killing cancer cells can help a patient recover from the disease. But great care must be taken in using radium for this purpose. Its radiation can also kill healthy cells. People who work with radium must take great care that they do not get the element on their skin, swallow it, or inhale its fumes. Marie Curie eventually developed leukemia and died in 1934 from the hazards of radium that she never knew.
Tags: death, Luminescence, Marya's, Radium
Conclusion: Our study revealed a proper circadian regulation profile of several clock- and tumor suppressor genes at defined points in time in the participants studied. These findings could provide important information regarding genes displaying the same expression profile in the gastrointestinal tract amounting to a physiological expression profile of healthy humans. In the future asynchronous regulations of those genes might be an additional assistant method to detect derivations distinguishing normal from malignant tissue or assessing risk factors for cancer.
PMID: 20798499 [PubMed - as supplied by publisher] (Source: Cancer Control)
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Source: MedWorm: Oral Cancer
Tags: Circadian, Clock, expression, Genes, human, Mucosa, Oral, Suppressor, tumor